Botanical Overview
Mahonia nervosa, commonly known as Cascade Oregon grape, is a perennial evergreen shrub in the Berberidaceae family. Native to the Pacific Northwest of North America, it is recognized for its bitter-tasting root and stem bark, traditionally used medicinally. Parts used include root, stem bark, and leaves.
Energetics
This plant is considered cooling and drying in nature, with bitter and astringent tastes. It is tonifying to the body’s qi and does not exhibit clear directionality.
Primary Actions
- Antimicrobial
- Bitter tonic
- Hepatoprotective
- Cholagogue (promotes bile flow)
- Anti-inflammatory
Indications
Western
- Dyspepsia
- Constipation
- Mild skin infections
- Inflammatory conditions
- Liver sluggishness
Syndromes
- Digestive sluggishness
- Biliary insufficiency
- Skin eruptions
TCM
No traditional use documented.
Ayurveda
No traditional use documented.
Unani
No traditional use documented.
Constituents & Mechanisms
Contains bioactive alkaloids such as berberine, palmatine, and jatrorrhizine, which confer antimicrobial, anti-inflammatory, and hepatoprotective effects.
Dosage & Preparations
- Tincture 1:5 45% ethanol 2-5 mL, 2-3 times daily
- Decoction of root bark 2-4 grams, twice daily
- Powdered root bark 1-3 grams, twice daily
Safety & Contraindications
Mahonia nervosa is generally safe when used appropriately but should be avoided during pregnancy and used cautiously during lactation due to insufficient data. Overdose may cause gastrointestinal discomfort. Potential interactions include inhibition of CYP450 enzymes, so concurrent use with other medications warrants caution.
Astrological Correspondences
No reliable astrological or elemental correspondences are documented for this species.
Selected References
- Mahonia nervosa (Cascade Oregon grape): Edible and Medicinal Plant Database – Plants For A Future
- Medicinal Plants of the Pacific West – Michael Moore (2012)
- Herbal Medicine Expanded Commission E Monographs – German Commission E (1998)
- Berberine and medicinal properties of Berberis species – NIH NCCIH (2020)