Botanical Overview
Podophyllum peltatum, commonly known as Mayapple, American mandrake, or Wild mandrake, belongs to the family Berberidaceae. It is native to Eastern North America. The primary parts used medicinally include the rhizome, root, and leaves.
Energetics
This herb is considered cooling and drying in nature, with a bitter taste. Its energetic directionality is descending, and it possesses a relaxing tonicity, primarily affecting the qi.
Primary Actions
- Laxative
- Antimitotic
- Vesicant
- Purgative
Indications
Western
- Constipation
- Warts
- Skin tumors
Syndromes
- Obstructive constipation
- Cutaneous neoplasms
- External fungal and viral lesions
TCM
No traditional Chinese medicine indications documented.
Ayurveda
No traditional Ayurvedic indications documented.
Unani
No traditional Unani indications documented.
Constituents & Mechanisms
Podophyllum peltatum contains important phytochemicals including podophyllotoxin (a potent cytotoxic lignan), lignans, flavonoids, and resins responsible for its antiviral, laxative, and antimitotic effects.
Dosage & Preparations
- Topical resin preparations for wart treatment are used at variable concentrations as guided professionally.
- Historical internal use of rhizome decoctions or tinctures exists but is not recommended without professional supervision due to toxicity risks.
Safety & Contraindications
This plant contains toxic compounds and should be used with caution. It is contraindicated in pregnancy, lactation, children, and patients with severe gastrointestinal conditions. Toxicity may cause gastrointestinal and neurological adverse effects. Topical use can cause local irritation and should avoid broken skin unless under professional care.
Astrological Correspondences
No reliable sources were found documenting planetary or elemental rulers.
Selected References
- Podophyllum peltatum – Mayapple. Plants For A Future.
- WHO Monographs on Selected Medicinal Plants – Volume 3. World Health Organization, 2007.
- Podophyllum. National Institutes of Health – MedlinePlus.
- Medicinal Use and Toxicology of Podophyllum peltatum. Smith et al., 2015.