Botanical Overview
Griffonia simplicifolia belongs to the Fabaceae family and is native to West and Central Africa. Commonly known as African black bean or Griffonia, its seeds are the primary part used medicinally. The seeds are valued for their high content of 5-Hydroxytryptophan (5-HTP), a precursor to serotonin.
Energetics
It is considered energetically neutral in temperature and moisture, with tastes described as bitter and sweet. Its directionality is descending, and it is tonifying primarily affecting the qi.
Primary Actions
- Anxiolytic
- Antidepressant
- Nervine
- Serotonergic
Indications
Western
- Anxiety
- Depression
- Insomnia
- Appetite control
Syndromes
- Serotonin deficiency
- Mood disorders
TCM
No well-documented traditional uses.
Ayurveda
No well-documented traditional uses.
Unani
No well-documented traditional uses.
Constituents & Mechanisms
The seeds contain significant levels of 5-Hydroxytryptophan (5-HTP), alkaloids, flavonoids, and glycosides. 5-HTP is a direct precursor to serotonin, which contributes to its antidepressant and anxiolytic effects.
Dosage & Preparations
- Seed extract standardized to 20% 5-HTP, typical dose 50-100 mg, 1-3 times daily
- Capsule 50-100 mg 5-HTP standardized extract
- Powdered seed extract
Safety & Contraindications
The seed extract is generally well tolerated but use caution when combining with other serotonergic agents due to the risk of serotonin syndrome. Not recommended during pregnancy or lactation due to insufficient safety data. Contraindicated with use of antidepressant drugs, particularly SSRIs and MAOIs.
Astrological Correspondences
No clear or reliably sourced astrological or elemental rulers identified.
Selected References
- Herbal Medicine: Biomolecular and Clinical Aspects, 2nd Edition
- A Review of 5-HTP in Depression – Birdsall TC, 2017
- Plants For A Future Database – Griffonia simplicifolia Profile