Botanical Overview
Xysmalobium undulatum (Family: Apocynaceae) is a medicinal plant native to Southern Africa. Commonly known as Uzara or Wild Cotton, the primary part used medicinally is the root. It has a longstanding traditional use in indigenous medicine.
Energetics
This herb is considered to have a neutral thermal effect and neutral moisture. It has a notably bitter taste and is tonifying in nature.
Primary Actions
- Antidiarrheal
- Cardiotonic
- Anti-inflammatory
Indications
Western
- Diarrhea
- Dysentery
- Stomach cramps
Syndromes
- Acute and chronic diarrhea
- Intestinal infections
TCM
Not documented
Ayurveda
Not documented
Unani
Not documented
Constituents & Mechanisms
The pharmacological effects derive mainly from cardiac glycosides such as cardenolides and other alkaloids present in the root, conferring antidiarrheal and cardiotonic actions.
Dosage & Preparations
- Tincture 1:5 40% ethanol 2-4 mL, 1-3 times daily
- Standardized extract containing 20–40 mg cardiac glycosides orally
- Powder made from dried root 0.5–1 g, 1-3 times daily
Safety & Contraindications
Use caution in patients with heart conditions due to cardiac glycoside content. It is contraindicated during pregnancy, lactation, and in individuals with cardiac arrhythmias. Avoid concurrent use with digitalis glycosides and monitor if combined with antiarrhythmic drugs. Overdose may lead to cardiac toxicity.
Astrological Correspondences
No reliably sourced planetary or elemental rulers documented.
Selected References
- European Medicines Agency (EMA) Herbal Monograph on Uzara root
- Pfaf.org database: Xysmalobium undulatum
- Medicinal Plants of South Africa by Watt and Breyer-Brandwijk (1962)
- van Wyk B.-E., Pharmacology and clinical use of Xysmalobium undulatum in gastrointestinal disorders (1996)